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Hi everyone,
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<div class="">… slightly off topic for those of you who are interested in electrical activity of neutrons, but may be of interest to the haemodynamic crowd.</div>
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<div class="">Best</div>
<div class="">Denis<br class="">
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<div class="">Begin forwarded message:</div>
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<span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">From:
</b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">Etienne Farcot <<a href="mailto:etienne.farcot@nottingham.ac.uk" class="">etienne.farcot@nottingham.ac.uk</a>><br class="">
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<span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Subject:
</b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class=""><b class="">[Maths-seminars] CMMB seminar 9 February - Rebecca Shipley</b><br class="">
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<span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Date:
</b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">4 February 2016 10:23:08 GMT<br class="">
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</b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class=""><<a href="mailto:maths-seminars-announce@lists.nottingham.ac.uk" class="">maths-seminars-announce@lists.nottingham.ac.uk</a>>, CMMB list <<a href="mailto:maths-cmmb@lists.nottingham.ac.uk" class="">maths-cmmb@lists.nottingham.ac.uk</a>><br class="">
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<div class="">Dear all,<br class="">
<br class="">
<br class="">
Next Tuesday for the CMMB seminar we will have the pleasure to welcome<br class="">
Rebecca Shipley, from UCL.<br class="">
<br class="">
Date and venue: 2pm Tuesday 9 Feburary, UP-POPE-C18<br class="">
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Title/Abstract:<br class="">
<br class="">
Development and Testing of New Mathematical Models for Tissue Blood Flow<br class="">
<br class="">
The vasculature is a 3D multiscale network comprised of a hierarchy of vessels that is frequently categorized according to vessel<br class="">
size. Although the geometry and topology of the vasculature is organ-specific, blood flows into an organ from a feeding artery, through the arterioles into the microcirculation, and exits through the venules then veins. Gas exchange occurs primarily in the
microcirculation and, indeed, the function of the vasculature is to bring oxygenated blood within a small distance of every tissue point in the body in order to meet metabolic demands. Modelling the flow of blood and solutes through these networks could play
a crucial role in, for example, controlling drug dosage and predicting efficacy, as well as understanding pathological scenarios such as myocardial ischaemia or local tumour microenvironments.<br class="">
Traditional modelling approaches have employed a discrete approach by<br class="">
solving equations for blood flow in each vessel of a network.<br class="">
However, recent advances in imaging methods have led to a wealth of data that describe vascular structure in a highly detailed way. As the<br class="">
resolution of these data increases, it is becoming too computationally<br class="">
intensive to simulate flow and mass transport in the complete<br class="">
vascular tree using a discrete approach. As such, continuum models must<br class="">
be developed that capture the key functional properties of blood flow.<br class="">
<br class="">
Continuum multiscale models that describe blood flow in the microcirculation, derived using the mathematical process of asymptotic homogenization, will be discussed. These models include both vascular and interstitial fluid transport (as it pertinent for the
leaky<br class="">
neovasculature of solid tumours). A strategy for combining discrete and<br class="">
continuum models to simulate transport in large network data sets will be presented, and results of testing this strategy on explicit examples<br class="">
of rat mesentery networks (with known flow solutions) will be demonstrated. Finally, applications of the modelling framework to large<br class="">
vascular data sets extracted using corrosion casting, micro-CT and optical imaging methods will be discussed for Tissue Blood Flow.<br class="">
<br class="">
<br class="">
Please let us know if you would like to meet the speaker in person.<br class="">
<br class="">
All the best,<br class="">
<br class="">
Etienne and Bindi<br class="">
<br class="">
.................................<br class="">
Etienne Farcot<br class="">
School of Mathematical Sciences<br class="">
University of Nottingham<br class="">
University Park<br class="">
Nottingham, NG7 2RD, UK<br class="">
<br class="">
tel: +44(0) 115 951 4943<br class="">
--<br class="">
<a href="http://ecmtb2016.org" class="">http://ecmtb2016.org</a><br class="">
.................................<br class="">
<br class="">
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